Drug-development Strategy for Undruggable Targets Using a Novel Target Degradation Technology CANDDY
Author:
Affiliation:
1. Research Institute for Science & Technology, Tokyo University of Science
Publisher
The Society of Japanese Women Scientists
Subject
General Medicine
Link
https://www.jstage.jst.go.jp/article/sjws/22/0/22_22005/_pdf
Reference16 articles.
1. 1) Khan, I., Rhett, J. M. & O’Bryan, J. P. Therapeutic targeting of RAS: New Hope for drugging the “undruggable”. Biochim. Biophys. Acta Mol. Cell Res. 1867, 118570 (2020).
2. 2) Fujimori, S., et al. Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data.Sci. Rep. 2, 691 (2012).
3. 3) Scott, D. E., Bayly, A. R., Abell, C. & Skidmore, J. Small molecules, bigtargets: Drug discovery faces the protein-protein interaction challenge. Nat. Rev. Drug Discov. 15, 533–550 (2016).
4. 4) Imanishi, S., et al. In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor. bioRxiv. 2021.04.23.441075
5. 5) Cromm, P. M. & Crews, C. M. Targeted protein degradation: From chemical biology to drug discovery. Cell Chem. Biol. 24, 1181–1190 (2017).
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