Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity-Reference-Cited by-同舟云学术

Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity

Published:2022-09-01 Issue:9 Volume:28 Page:457-468
ISSN:1937-3384
Container-title:Tissue Engineering Part C: Methods
language:en
Short-container-title:Tissue Engineering Part C: Methods

Author:

Oguntuyo Kasoorelope¹^ORCID,Schuftan David¹,Guo Jingxuan²^ORCID,Simmons Daniel¹,Bhagavan Druv¹^ORCID,Moreno Jonathan D.³,Kang Po Wei¹^ORCID,Miller Evan⁴^ORCID,Silva Jonathan R.¹^ORCID,Huebsch Nathaniel¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.

2. Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri, USA.

3. Division of Cardiology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.

4. Department of Chemistry, University of California, Berkeley, Berkeley, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.liebertpub.com/doi/pdf/10.1089/ten.tec.2022.0053

Reference37 articles.

1. Diagnosing the decline in pharmaceutical R&D efficiency

2. Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

3. The impact of drug-induced QT interval prolongation on drug discovery and development

4. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

5. Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform

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4. Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy;2023-10-31

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