An Optimized Automated Assay for Determination of Metabolic Stability Using Hepatocytes: Assay Validation, Variance Component Analysis, and In Vivo Relevance-Reference-Cited by-同舟云学术

An Optimized Automated Assay for Determination of Metabolic Stability Using Hepatocytes: Assay Validation, Variance Component Analysis, and In Vivo Relevance

Published:2007-06 Issue:3 Volume:5 Page:403-416
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Jacobson Lykke¹,Middleton Brian²,Holmgren Jan¹,Eirefelt Stefan¹,Fröjd Maria¹,Blomgren Anders¹,Gustavsson Lena¹

Affiliation:

1. Department of Drug Metabolism, Pharmacokinetics, and Bioanalysis, AstraZeneca R&D Lund, Lund, Sweden.

2. Discovery Enabling Capabilities and Sciences, AstraZeneca Alderley Park, Alderley Park, UK.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2007.059

Reference29 articles.

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3. EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

4. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

5. INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC UPTAKE AND BILIARY EXCRETION OF VALSARTAN, A SELECTIVE ANTAGONIST OF THE ANGIOTENSIN II AT1-RECEPTOR, IN HUMANS

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