How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery-Reference-Cited by-同舟云学术

How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery

Published:2017-12 Issue: Volume:110 Page:37-50
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Teague Simon,Valko Klara

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference24 articles.

1. Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates;Braggio;Expert Opin. Drug Discov.,2010

2. Partitioning of solutes in different solvent systems: the contribution of hydrogen-bonding capacity and polarity;El Tayar;J. Pharm. Sci.,1991

3. Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics;Grime,2013

4. Estimation of volume of distribution in humans from HPLC measurements of human serum albumin binding and immobilized artificial membrane partitioning;Hollosy;J. Med. Chem.,2006

5. Physiochemical drug properties associated with in vivo toxicological outcomes;Hughes;Bioorganic Med. Chem. Lett.,2008

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