Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen-Reference-Cited by-同舟云学术

Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen

Published:2023-04-01 Issue:3 Volume:21 Page:89-96
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Bender Aaron M.¹²^ORCID,Valentine Michael S.³,Bauer Joshua A.⁴⁵,Days Emily⁴,Lindsley Craig W.¹²⁵⁶,Merryman W. David³

Affiliation:

1. Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.

2. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.

3. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.

4. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.

5. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.

6. Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/adt.2022.116

Reference23 articles.

1. 1. Setola V, Roth BL. The Emergence of Serotonin 5-HT2B Receptors as DRUG Antitargets. In: Antitargets: Prediction and Prevention of Drug Side Effects. (Vaz RJ, Klabunde T. eds.) Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany; 2008.

2. Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2BReceptor Agonists: Implications for Drug Safety Assessment

3. Evidence for Possible Involvement of 5-HT 2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

4. Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

5. 3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

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