Dual <i>N</i><sup>6</sup>/C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors-Reference-Cited by-同舟云学术

Dual N⁶/C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors

Published:2023-12-26 Issue:1 Volume:15 Page:81-86
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Krols Simon¹^ORCID,Matteucci Federica¹,Van Hecke Kristof²^ORCID,Caljon Guy³,Jacobson Kenneth A.⁴^ORCID,Van Calenbergh Serge¹^ORCID

Affiliation:

1. Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium

2. XStruct, Department of Chemistry, Ghent University, Krijgslaan 281-S3, 9000 Ghent, Belgium

3. Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium

4. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Fonds Wetenschappelijk Onderzoek

Bijzonder Onderzoeksfonds UGent

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00427

Reference34 articles.

1. The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2. The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

3. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?