Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region-Reference-Cited by-同舟云学术

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Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region

Published:2017-08 Issue:4 Volume:27 Page:232-237
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Nakajima Mado¹,Kasuya Takeshi¹,Yokota Shinnichi¹,Onishi Reina²,Ikehara Tatsuya³,Kugimiya Akira¹,Watanabe Ayahisa²

Affiliation:

1. Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Toyonaka, Japan.

2. Physicochemical & Preformulation, Research Laboratory for Development, Shionogi & Co., Ltd., Toyonaka, Japan.

3. Biomarker R&D Department, Shionogi & Co., Ltd., Toyonaka, Japan.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2017.0669

Reference25 articles.

1. Antisense Drug Technology

2. The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

3. Ein neuer Zugang zu 2?-O-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide

4. Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

5. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

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