Adeno-Associated Virus-Mediated Gene Transfer to Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses-Reference-Cited by-同舟云学术

Adeno-Associated Virus-Mediated Gene Transfer to Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses

Published:2009-09 Issue:9 Volume:20 Page:930-942
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Gao Guangping¹²,Wang Qiang¹³,Calcedo Roberto¹,Mays Lauren¹,Bell Peter¹,Wang Lili¹,Vandenberghe Luk H.¹,Grant Rebecca¹,Sanmiguel Julio¹,Furth Emma E.⁴,Wilson James M.¹

Affiliation:

1. Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.

2. Present address: Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605.

3. Present address: Vaccine Research Institute, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China 510630.

4. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2009.060

Reference37 articles.

1. Potential of AAV vectors in the treatment of metabolic disease

2. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state

3. Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

4. Clinical Gene Transfer Studies for Hemophilia A

5. Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models

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