Vector Affinity and Receptor Distribution Define Tissue-Specific Targeting in an Engineered AAV Capsid-Reference-Cited by-同舟云学术

Vector Affinity and Receptor Distribution Define Tissue-Specific Targeting in an Engineered AAV Capsid

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Martino R. Alexander¹,Wang Qiang¹,Xu Hao¹,Hu Gui¹,Bell Peter¹,Arroyo Edgardo J.¹,Sims Joshua J.¹,Wilson James M.¹^ORCID

Affiliation:

1. Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Novel methods for measuring adeno-associated virus (AAV)-receptor affinities, especially in relation to vector performance in vivo , would be useful to capsid engineers as they develop AAV vectors for gene therapy applications and characterize their interactions with native or engineered receptors. Here, we use the AAV-PHP.B-Ly6a model system to assess the impact of receptor affinity on the systemic delivery and endothelial penetration properties of AAV-PHP.B vectors.

Funder

Amicus Therapeutics

Passage Bio

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00174-23

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