Identification of a Novel Heart–Liver Axis: Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A 2 to Modulate Lipid Metabolism and Inflammation in the Liver

Author:

Hernandez‐Anzaldo Samuel1,Berry Evan1,Brglez Vesna2,Leung Dickson1,Yun Tae Jin34,Lee Jun Seong35,Filep Janos G.6,Kassiri Zamaneh789,Cheong Cheolho35,Lambeau Gérard2,Lehner Richard1011,Fernandez‐Patron Carlos189

Affiliation:

1. Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

2. Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice‐Sophia Antipolis, Valbonne, France

3. Laboratory of Cellular Physiology and Immunology, Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada

4. Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada

5. Department of Microbiology and Immunology, University of Montreal, Quebec, Canada

6. Innate Immunity System (Inflammation) and Vascular Immunology, The Maisonneuve‐Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada

7. Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

8. Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

9. Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

10. Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

11. Group on Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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