Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats

Author:

Palabiyik Esra1,Sulumer Ayse Nurseli1,Uguz Handan1,Avci Bahri1,Askin Seda2,Askin Hakan1

Affiliation:

1. Department of Genetics Atatürk University Erzurum Türkiye

2. Department of Medical Services and Techniques Ataturk University Erzurum Turkey

Abstract

AbstractThe walnut fruit diaphragm (WFD) is an economically and ecologically important by‐product of the Juglandaceae family. Components in the ethanolic extract of WFD (E‐WFD) were identified by gas chromatography‐mass spectroscopy (GC‐MS). In our study, the lipid‐lowering effect, antioxidant potential, and anti‐inflammatory properties of E‐WFD in the blood, heart, and liver tissues of rats (♂, Wistar) with hyperlipidemia caused by Triton WR‐1339 were determined using biochemical, histopathological, and molecular techniques. Experimental animals for analysis are as follows: K1: healthy control group, K2: E‐WFD (150 mg, o.d.), K3: E‐WFD (300 mg, o.d.), K4: HL (hyperlipidemic group) (400 mg kg–1 Triton WR‐1339, i.p.), K5: HL + E‐WFD (300 mg) grouped as (n = 6). After the application, anti‐hyperlipidemic analysis (TC, TG, LDL‐C, HDL‐C, ALT, and AST), oxidative stress (MDA, SOD, and CAT) parameters measurement, histopathological examinations, and inflammatory biomarker genes (Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α and Srebp‐1c) expression stability were determined by q‐RT PCR. With the E‐WFD application, there was a decrease in TC and TG levels and an increase in HDL‐C. Oxidative stress decreased by changing MDA, SOD, and CAT levels. Histopathological deterioration in the tissues changed positively. In addition, E‐WFD showed significant inhibitory properties on Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α, and Srebp‐1c genes.Practical Applications: It is known that hyperlipidemia causes a wide range of diseases. In this study, the effect of walnut fruit diaphragm (WFD) ethanol extract was compared against the effect of Triton WR‐1339‐induced hyperlipidemia on rats. With the use of WFD, the damages caused by hyperlipidemia were significantly ameliorated. Accordingly, it is expected to contribute to the pharmacology, food and cosmetic industries as a very valuable alternative product.]

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,General Chemistry,Food Science,Biotechnology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Histopathological and Antioxidant Effects of Bromelain on Kidney Tissue of Tyloxapol-Induced Hyperlipidemic Rats;Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi;2024-08-31

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3