1. From the Department of Health Sciences (M.D.T., N.A.S., P.R.B.), University of Leicester; the Department of Cardiovascular Sciences (S.M.R., P.B., C.B., J.O., D.C., J.G., S.H., T.S., C.R., N.J.S.), University of Leicester, Glenfield Hospital; and the Department of Genetics (M.D.T., N.A.S., P.R.B.), University of Leicester, Leicester; and the Department of Clinical Pharmacology and Barts and the London Genome Centre (S.N., M.C., P.B.M.), Barts and the London School of Medicine, London, England.