1. From the Department of Internal Medicine and Molecular Science (H.K., S.K., M.K., T.F., Y.M.), Graduate School of Medicine, Osaka University, Osaka, Japan; Molecular Cardiology/Whitaker Cardiovascular Institute (N.O., K.W.), Boston University School of Medicine, Boston, Mass; Lead Discovery Research Laboratories (Y.A.), Sankyo Co Ltd, Tokyo, Japan.