Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery
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Published:2024-02-07
Issue:2
Volume:17
Page:215
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ISSN:1424-8247
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Container-title:Pharmaceuticals
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language:en
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Short-container-title:Pharmaceuticals
Author:
Fiorotti Amanda Machado1, Gomes Amanda Cristina Araújo1, Bortoli Amanda Motta1, Brito Beatriz Bobbio de1, Nunes Karolini Zuqui1ORCID, Haraguchi Fabiano Kenji1ORCID, Bolsoni-Lopes Andressa1ORCID
Affiliation:
1. Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, Brazil
Abstract
The remission of obesity-related diseases following bariatric surgery appears to result from the reorganization of metabolic and hormonal pathways involving adipokines. This study aimed to investigate the relationship between changes in body adiposity and serum adipokine levels, as well as the association between variations in adiponectin or resistin levels and cardiometabolic risk blood biomarkers before and after Roux-en-Y gastric bypass. A longitudinal and prospective study was conducted with bariatric surgery patients. Anthropometric, body composition and blood biochemical parameters were measured before and at 2 and 6 months post-surgery. The data were analyzed using ANOVA, Pearson or Spearman correlation, and simple linear regression with a significance level of p < 0.05. Among 36 mostly female patients aged 30 to 39 years, significant reductions in body weight (−26.8%), fat mass (−50%), waist circumference (−18%) and waist-to-height ratio (−22%) were observed post-surgery. Serum adiponectin levels increased (+107%), while resistin (−12.2%), TNF-α (−35%), and PAI-1 (−11.1%) decreased. Glucose, insulin, CRP, cholesterol, LDL-c, triglycerides, and vitamin D also decreased. Waist circumference variation showed a positive correlation with PAI-1 and TNF-α and a negative correlation with adiponectin. The total fat mass showed a positive correlation with PAI-1. Adiponectin variation correlated negatively with glucose, resistin, and CRP but positively with HDL-c. Resistin showed a positive correlation with insulin and CRP. In conclusion, 6 months post-bariatric surgery, reducing abdominal adiposity had a more significant impact on serum adipokine levels than total fat mass. Adiponectin increase and resistin decrease acted as endocrine mediators driving the remission of cardiometabolic risk biomarkers in individuals with obesity following Roux-en-Y gastric bypass.
Funder
Foundation for Research and Innovation Support of Espírito Santo—FAPES
Reference50 articles.
1. World Health Organization (2017). Obesity and Overweight, World Health Organization. 2. Ministry of Health (Brazil) (2023, January 17). Vigitel Brazil 2021: Surveillance of Risk and Protective Factors for Chronic Diseases by Telephone Survey: Estimates of Frequency and Sociodemographic Distribution of Risk and Protective Factors for Chronic Diseases in the Capitals of the 26 Brazilian States and the Federal District in 2021. Brasília, 2021. Ministry of Health, Brasília, 2020. 128p. ISBN 978-65-5993-195-8. Publisher MS – OS 2022/0088, Available online: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/vigitel/vigitel-brasil-2021-estimativas-sobre-frequencia-e-distribuicao-sociodemografica-de-fatores-de-risco-e-protecao-para-doencas-cronicas. 3. The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome;Faienza;Intern. Emerg. Med.,2016 4. Feijóo-Bandín, S., Aragón-Herrera, A., Moraña-Fernández, S., Anido-Varela, L., Tarazón, E., Roselló-Lletí, E., Portolés, M., Moscoso, I., Gualillo, O., and González-Juanatey, J.R. (2020). Adipokines and Inflammation: Focus on Cardiovascular Diseases. Int. J. Mol. Sci., 21. 5. Obesity subtypes, related biomarkers & heterogeneity;Mayoral;Indian J. Med. Res.,2020
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