Research Opportunities in Stroke Prevention for Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop-Reference-Cited by-同舟云学术

Research Opportunities in Stroke Prevention for Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop

Published:2023-03 Issue:3 Volume:54 Page:
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Go Alan S.¹²³^ORCID,Al-Khatib Sana M.⁴^ORCID,Desvigne-Nickens Patrice⁵^ORCID,Bansal Nisha⁶^ORCID,Bushnell Cheryl D.⁷^ORCID,Fang Margaret C.⁸^ORCID,Freeman James V.⁹¹⁰^ORCID,Gage Brian F.¹¹^ORCID,Hanke Thorsten¹²,Hylek Elaine M.¹³,Lopes Renato D.⁴^ORCID,Noseworthy Peter A.¹⁴^ORCID,Reddy Vivek Y.¹⁵^ORCID,Singer Daniel E.¹⁶^ORCID,Thomas Kevin L.⁴^ORCID,True Hills Mellanie¹⁷^ORCID,Turakhia Mintu P.¹⁸¹⁹^ORCID,Zieman Susan J.²⁰,Cooper Lawton S.⁵^ORCID,Benjamin Emelia J.²¹²²^ORCID

Affiliation:

1. Division of Research, Kaiser Permanente Northern California, Oakland (A.S.G.).

2. Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA (A.S.G.).

3. Departments of Epidemiology, Biostatistics and Medicine, University of California, San Francisco (A.S.G.).

4. Division of Cardiology and Duke Clinical Research Institute, Duke University, Durham, NC (S.M.A.-K., R.D.L., K.L.T.).

5. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.D.-N., L.S.C.).

6. Division of Nephrology, University of Washington, Seattle (N.B.).

7. Department of Neurology, Wake Forest University, Winston-Salem, NC (C.D.B.).

8. Division of Hospital Medicine, University of California, San Francisco (M.C.F.).

9. Department of Medicine, Yale University, New Haven, CT (J.V.F.).

10. Center for Outcomes Research and Evaluation, Yale New Haven Health Services Corporation, CT (J.V.F.).

11. Department of Medicine, Washington University, St Louis, MO (B.F.G.).

12. Department of Cardiac Surgery, Asklepios Klinikum Harburg-Hamburg, Germany (T.H.).

13. Department of Medicine, Boston University, MA (E.M.H.).

14. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (P.A.N.).

15. Department of Medicine, Icahn School of Medicine, New York, NY (V.Y.R.).

16. Division of General Internal Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston (D.E.S.).

17. StopAfib.org, American Foundation for Women’s Health, Decatur, TX (M.T.H.).

18. Veterans Affairs Palo Alto Health Care System, CA (M.P.T.).

19. Center for Digital Health, Stanford University, CA (M.P.T.).

20. Division of Geriatrics and Clinical Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, MD (S.J.Z.).

21. Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, MA (E.J.B.).

22. Department of Epidemiology, Boston University School of Public Health, MA (E.J.B.).

Abstract

Atrial fibrillation (AF) is one of the strongest risk factors for ischemic stroke, which is a leading cause of disability and death. Given the aging population, increasing prevalence of AF risk factors, and improved survival in those with cardiovascular disease, the number of individuals affected by AF will continue increasing over time. While multiple proven stroke prevention therapies exist, important questions remain about the optimal approach to stroke prevention at the population and individual patient levels. Our report summarizes the National Heart, Lung, and Blood Institute virtual workshop focused on identifying key research opportunities related to stroke prevention in AF. The workshop reviewed major knowledge gaps and identified targeted research opportunities to advance stroke prevention in AF in the following areas: (1) improving risk stratification tools for stroke and intracranial hemorrhage; (2) addressing challenges with oral anticoagulants; and (3) delineating the optimal roles of percutaneous left atrial appendage occlusion and surgical left atrial appendage closure/excision. This report aims to promote innovative, impactful research that will lead to more personalized, effective use of stroke prevention strategies in people with AF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

Reference78 articles.

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