Research Priorities in Atrial Fibrillation Screening-Reference-Cited by-同舟云学术

Research Priorities in Atrial Fibrillation Screening

Published:2021-01-26 Issue:4 Volume:143 Page:372-388
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Benjamin Emelia J.¹²^ORCID,Go Alan S.³⁴⁵^ORCID,Desvigne-Nickens Patrice⁶^ORCID,Anderson Christopher D.⁷^ORCID,Casadei Barbara⁸^ORCID,Chen Lin Y.⁹^ORCID,Crijns Harry J.G.M.¹⁰^ORCID,Freedman Ben¹¹^ORCID,Hills Mellanie True¹²^ORCID,Healey Jeff S.¹³^ORCID,Kamel Hooman¹⁴^ORCID,Kim Dong-Yun¹⁵^ORCID,Link Mark S.¹⁶^ORCID,Lopes Renato D.¹⁷^ORCID,Lubitz Steven A.¹⁸^ORCID,McManus David D.¹⁹^ORCID,Noseworthy Peter A.²⁰^ORCID,Perez Marco V.¹^ORCID,Piccini Jonathan P.¹⁷^ORCID,Schnabel Renate B.²¹²²^ORCID,Singer Daniel E.²³^ORCID,Tieleman Robert G.²⁴²⁵^ORCID,Turakhia Mintu P.²⁶²⁷^ORCID,Van Gelder Isabelle C.²⁴^ORCID,Cooper Lawton S.⁶^ORCID,Al-Khatib Sana M.¹⁷^ORCID

Affiliation:

1. Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, MA (E.J.B.).

2. Department of Epidemiology, Boston University School of Public Health, MA (E.J.B.).

3. Division of Research, Kaiser Permanente Northern California, Oakland (A.S.G.).

4. Departments of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (A.S.G.).

5. Departments of Medicine, Health Research, and Policy (A.S.G.), Stanford University, CA.

6. Division of Cardiovascular Sciences (P.D.-N., L.S.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

7. Department of Neurology, Center for Genomic Medicine, and McCance Center for Brain Health, Massachusetts General Hospital, Boston (C.D.A.).

8. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK (B.C.).

9. Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis (L.Y.C.).

10. Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, the Netherlands (H.J.G.M.C.).

11. Heart Research Institute, Charles Perkins Centre, and Concord Hospital Department of Cardiology, Concord Clinical School, University of Sydney, Australia (B.F.).

12. StopAfib.org, American Foundation for Women’s Health, Decatur, TX (M.T.H.).

13. Population Health Research Institute, McMaster University, Hamilton, ON, Canada (J.S.H.).

14. Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, NY (H.K.).

15. Office of Biostatistics Research (D.-Y.K.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

16. Department of Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (M.S.L.).

17. Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.D.L., J.P.P., S.M.A.-K.).

18. Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston (S.A.L.).

19. Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester (D.D.M.).

20. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (P.A.N.).

21. Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany (R.B.S.).

22. DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Germany (R.B.S.).

23. Division of General Internal Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, (D.E.S.).

24. Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (I.C.V.G., R.G.T.).

25. Department of Cardiology, Martini Hospital, Groningen, the Netherlands (R.G.T.).

26. Center for Digital Health (M.P.T.), Stanford University, CA.

27. Veterans Affairs Palo Alto Health Care System, CA (M.P.T.).

Abstract

Clinically recognized atrial fibrillation (AF) is associated with higher risk of complications, including ischemic stroke, cognitive decline, heart failure, myocardial infarction, and death. It is increasingly recognized that AF frequently is undetected until complications such as stroke or heart failure occur. Hence, the public and clinicians have an intense interest in detecting AF earlier. However, the most appropriate strategies to detect undiagnosed AF (sometimes referred to as subclinical AF) and the prognostic and therapeutic implications of AF detected by screening are uncertain. Our report summarizes the National Heart, Lung, and Blood Institute’s virtual workshop focused on identifying key research priorities related to AF screening. Global experts reviewed major knowledge gaps and identified critical research priorities in the following areas: (1) role of opportunistic screening; (2) AF as a risk factor, risk marker, or both; (3) relationship between AF burden detected with long-term monitoring and outcomes/treatments; (4) designs of potential randomized trials of systematic AF screening with clinically relevant outcomes; and (5) role of AF screening after ischemic stroke. Our report aims to inform and catalyze AF screening research that will advance innovative, resource-efficient, and clinically relevant studies in diverse populations to improve the diagnosis, management, and prognosis of patients with undiagnosed AF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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