Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure

Author:

Al-Khatib Sana M.1ORCID,Benjamin Emelia J.2,Albert Christine M.3,Alonso Alvaro4,Chauhan Cynthia5,Chen Peng-Sheng6,Curtis Anne B.7,Desvigne-Nickens Patrice8,Ho Jennifer E.9,Lam Carolyn S.P.10,Link Mark S.11,Patton Kristen K.12,Redfield Margaret M.13,Rienstra Michiel14,Rosenberg Yves8,Schnabel Renate15,Spertus John A.16,Stevenson Lynne Warner17,Hills Mellanie True18,Voors Adriaan A.14,Cooper Lawton S.8,Go Alan S.192021

Affiliation:

1. Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (S.M.A.).

2. Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, and Department of Epidemiology, Boston University School of Public Health, MA (E.J.B.).

3. Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (C.M.A.).

4. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.).

5. Patient representative, Wichita, KS (C.C.).

6. The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis (P.-S.C.).

7. Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, NY (A.B.C.).

8. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (P.D.N., Y.R., L.S.C.).

9. Corrigan Minehan Heart Center, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (J.E.H.).

10. National Heart Centre Singapore and Duke-National University of Singapore (C.S.P.L.).

11. Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (M.S.L.).

12. Division of Cardiology, University of Washington, Seattle (K.K.P.).

13. Department of Cardiovascular Medicine at Mayo Clinic, Rochester, MN (M.M.R.).

14. Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (M.R., A.A.V.).

15. Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany, German Center for Cardiovascular Research, partner site Hamburg/Kiel/Luebeck (R.B.S.).

16. Cardiovascular Division, Saint Luke’s Mid America Heart Institute/University of Missouri-Kansas City, Kansas City, MO (J.A.S.).

17. Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN (L.W.S.).

18. StopAfib.org, American Foundation for Women’s Health, Decatur, TX (M.T.H.).

19. Division of Research, Kaiser Permanente Northern California, Oakland (A.S.G.).

20. Departments of Epidemiology, Biostatistics and Medicine, University of California, San Francisco (A.S.G.).

21. Departments of Medicine, Health Research and Policy, Stanford University, CA (A.S.G.).

Abstract

The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on the intersection between AF and HF. This article summarizes the proceedings of a virtual workshop convened by the US National Heart, Lung, and Blood Institute to identify important research opportunities in AF and HF. Key knowledge gaps were reviewed and research priorities were proposed for characterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing HF in people with AF; preventing AF in individuals with HF; and addressing symptom burden and health status outcomes in AF and HF. These research priorities will hopefully help inform, encourage, and stimulate innovative, cost-efficient, and transformative studies to enhance the outcomes of patients with AF and HF.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference76 articles.

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