Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells-Reference-Cited by-同舟云学术

Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells

Published:2021-08-19 Issue:18 Volume:32 Page:1624-1633
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Kalinin Alexandr A.¹²³,Hou Xinhai¹⁴²,Ade Alex S.²,Fon Gordon-Victor²,Meixner Walter²,Higgins Gerald A.²,Sexton Jonathan Z.⁵⁶⁷,Wan Xiang¹,Dinov Ivo D.²³⁸,O’Meara Matthew J.²,Athey Brian D.²⁸⁹

Affiliation:

1. Shenzhen Research Institute of Big Data, Chinese University of Hong Kong–Shenzhen, Shenzhen 518172, Guangdong, China

2. Department of Computational Medicine and Bioinformatics

3. Statistics Online Computational Resource (SOCR), Health Behavior and Biological Sciences

4. School of Science and Engineering, Chinese University of Hong Kong–Shenzhen, Shenzhen 518172, Guangdong, China

5. Department of Internal Medicine, Gastroenterology, Michigan Medicine

6. Department of Medicinal Chemistry, College of Pharmacy

7. Center for Drug Repurposing

8. Michigan Institute for Data Science (MIDAS), and

9. Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109

Abstract

Valproic acid-induced chromatin remodeling is reflected in time-dependent changes of 3D nuclear morphology of astrocyte cells potentially pertinent to astrocyte-to-neurons reprogramming. 4D morphometry allows accurate characterization of these changes, including increased nuclear size and higher shape irregularity under VPA treatment.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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