Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray-Reference-Cited by-同舟云学术

Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Camerini David¹²,Randall Arlo Z.¹,Trappl-Kimmons Krista¹,Oberai Amit¹,Hung Christopher¹,Edgar Joshua¹,Shandling Adam¹,Huynh Vu¹,Teng Andy A.¹,Hermanson Gary¹,Pablo Jozelyn V.¹,Stumpf Megan M.³,Lester Sandra N.³,Harcourt Jennifer³,Tamin Azaibi³,Rasheed Mohammed³,Thornburg Natalie J.³,Satheshkumar Panayampalli S.³,Liang Xiaowu¹,Kennedy Richard B.⁴,Yee Angela¹,Townsend Michael³,Campo Joseph J.¹

Affiliation:

1. Antigen Discovery Incorporated (ADI), Irvine, California, USA

2. University of California, Irvine, California, USA

3. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Mayo Clinic, Rochester, Minnesota, USA

Abstract

With novel mutant SARS-CoV-2 variants of concern on the rise, knowledge of immune specificities against SARS-CoV-2 proteins is increasingly important for understanding the impact of structural changes in antibody-reactive protein epitopes on naturally acquired and vaccine-induced immunity, as well as broader topics of cross-reactivity and viral evolution. A multi-coronavirus protein microarray used to map the binding of COVID-19 patient antibodies to SARS-CoV-2 proteins and protein fragments as well as to the proteins of four other coronaviruses that infect humans has shown specific regions of SARS-CoV-2 proteins that are highly reactive with patient antibodies and revealed cross-reactivity of these antibodies with other human coronaviruses.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01416-21

Reference42 articles.

1. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.

2. Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period

3. Estimates of the severity of coronavirus disease 2019: a model-based analysis

4. Antibody responses to SARS-CoV-2 in patients with COVID-19

5. Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dissecting humoral immune responses to an MVA-vectored MERS-CoV vaccine in humans using a systems serology approach;iScience;2024-08

2. Enhanced Assessment of Cross-Reactive Antigenic Determinants within the Spike Protein;International Journal of Molecular Sciences;2024-07-26

3. Characterization of antibody response to SARS-CoV-2 Orf8 from three waves of COVID-19 outbreak in Thailand;PLOS ONE;2024-05-20

4. Profiling of linear B-cell epitopes against human coronaviruses in pooled sera sampled early in the COVID-19 pandemic;2024-03-01

5. Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation;mBio;2024-01-16