Therapeutic Efficacy of Poly( dl -Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice-Reference-Cited by-同舟云学术

Therapeutic Efficacy of Poly( dl -Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice

Published:2001-01 Issue:1 Volume:45 Page:363-366
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dutt Manisha¹,Khuller G. K.¹

Affiliation:

1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India

Abstract

ABSTRACT Poly( dl -lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H 37 Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.363-366.2001

Reference15 articles.

1. Biodegradation and biocompatibility of PLA and PLGA microspheres.;Anderson J. M.;Adv. Drug Deliv. Rev.,1997

2. Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis -Infected Macrophages

3. Large porous particles for pulmonary drug delivery.;Edwards D. A.;Science,1997

4. Sustained release of isoniazid in vivo from a single implant of a biodegradable polymer.;Gangadharam P. R. J.;Tubercle,1991

5. Sustained release of isoniazid in vivo from a biodegradable polymer implant. Proceedings of the 24th Joint Conference on Tuberculosis. U.S.-Japan Cooperative Medical Science Programme.;Gangadharam P. R. J.;Tubercle,1989

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Micro-nanoemulsion and nanoparticle-assisted drug delivery against drug-resistant tuberculosis: recent developments;Clinical Microbiology Reviews;2023-12-20

2. Niosomes in Tuberculosis;Tubercular Drug Delivery Systems;2023

3. Application of Nanoemulsion in Tuberculosis Treatment;Handbook of Research on Nanoemulsion Applications in Agriculture, Food, Health, and Biomedical Sciences;2022

4. New in vitro model to evaluate kinetics of antimycobacterial drug release from bioresorbable polymeric carriers;MicroRNA in ocular pathology;2020-08

5. Nanotechnology-based approaches for tuberculosis treatment;Nanotechnology Based Approaches for Tuberculosis Treatment;2020