Large Porous Particles for Pulmonary Drug Delivery-Reference-Cited by-同舟云学术

Large Porous Particles for Pulmonary Drug Delivery

Published:1997-06-20 Issue:5320 Volume:276 Page:1868-1872
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Edwards David A.¹²³⁴⁵,Hanes Justin¹²³⁴⁵,Caponetti Giovanni¹²³⁴⁵,Hrkach Jeffrey¹²³⁴⁵,Ben-Jebria Abdelaziz¹²³⁴⁵,Eskew Mary Lou¹²³⁴⁵,Mintzes Jeffrey¹²³⁴⁵,Deaver Daniel¹²³⁴⁵,Lotan Noah¹²³⁴⁵,Langer Robert¹²³⁴⁵

Affiliation:

1. D. A. Edwards, A. Ben-Jebria, J. Mintzes, Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA.

2. J. Hanes, J. Hrkach, R. Langer, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. G. Caponetti, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, and Department of Pharmacy, Universite di Parma, 43100 Parma, Italy.

4. M. L. Eskew, Environmental Resources Research Institute, Pennsylvania State University, Fenske Laboratory, University Park, PA 16802, USA.

5. D. Deaver, Department of Animal Science, Pennsylvania State University, 324 Henning Building, University Park, PA 16802, USA.

Abstract

A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation. Particles with mass densities less than 0.4 gram per cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs' natural clearance mechanisms until the inhaled particles delivered their therapeutic payload. Inhalation of large porous insulin particles resulted in elevated systemic levels of insulin and suppressed systemic glucose levels for 96 hours, whereas small nonporous insulin particles had this effect for only 4 hours. High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Einarsson O., et al., Ann. N.Y. Acad. Sci. 762, 89 (1995).

2. Niven R., Crit. Rev. Ther. Drug Carrier Syst. 12, 151 (1995).

3. S. J. Smith and J. A. Bernstein in Inhalation Aerosols A. J. Hickey Ed. (Dekker New York 1996) pp. 233–269.

4. J. S. Patton and R. M. Platz Adv. Drug Delivery Rev. 8 179 (1992).

5. I. Gonda in Topics in Pharmaceutical Sciences 1991 D. J. A. Crommelin and K. K. Midha Eds. (Medpharm Scientific Stuttgart 1992) pp. 95–115.

Cited by 1076 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dandelion inspired microparticles with highly efficient drug delivery to deep lung;Colloids and Surfaces B: Biointerfaces;2024-12

2. The environmental burden of inhalation;European Journal of Pharmaceutical Sciences;2024-09

3. Different Carriers for Use in Dry Powder Inhalers: Characteristics of Their Particles;Journal of Aerosol Medicine and Pulmonary Drug Delivery;2024-08-09

4. Lattice Boltzmann simulation on particle suspensions containing porous particles in a narrow channel;Physics of Fluids;2024-08-01

5. Hematopoietic responses to metal-organic frameworks in adult mice following pulmonary exposure;Journal of Environmental Sciences;2024-08