TEM-187, a New Extended-Spectrum β-Lactamase with Weak Activity in a Proteus mirabilis Clinical Strain-Reference-Cited by-同舟云学术

TEM-187, a New Extended-Spectrum β-Lactamase with Weak Activity in a Proteus mirabilis Clinical Strain

Published:2013-05 Issue:5 Volume:57 Page:2410-2412
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Corvec Stéphane¹²,Beyrouthy Racha³⁴⁵,Crémet Lise¹²,Aubin Guillaume Ghislain¹²,Robin Frédéric³⁴,Bonnet Richard³⁴,Reynaud Alain¹²

Affiliation:

1. Service de Bactériologie-Hygiène, CHU de Nantes, Institut de Biologie, Nantes, France

2. Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, Nantes, France

3. CHU Clermont-Ferrand, Centre de Biologie, Laboratoire de Bactériologie Clinique, Clermont-Ferrand, France

4. Clermont Université, Université d'Auvergne, Evolution des Bactéries Pathogènes et Susceptibilité Génétique de l'Hôte, Clermont-Ferrand, France

5. Health and Environment Microbiology Laboratory, AZM Research Center of Biotechnology, Doctoral School of Sciences and Technology, Lebanese University, Tripoli, Lebanon

Abstract

ABSTRACT A Proteus mirabilis clinical strain (7001324) was isolated from urine sample of a patient hospitalized in a long-term-care facility. PCR and cloning experiments performed with this strain identified a novel TEM-type β-lactamase (TEM-187) differing by four amino acid substitutions (Leu21Phe, Arg164His, Ala184Val, and Thr265Met) from TEM-1. This characterization provides further evidence for the diversity of extended-spectrum β-lactamases (ESBL) produced by P. mirabilis and for their potential spread to other Enterobacteriaceae due to a lack of sensitive detection methods used in daily practice.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01761-12

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