Emerging Extended-Spectrum β-Lactamases in Proteus mirabilis

Author:

Pagani Laura1,Migliavacca Roberta1,Pallecchi Lucia2,Matti Cecilia3,Giacobone Ernesto3,Amicosante Gianfranco4,Romero Egidio1,Rossolini Gian Maria2

Affiliation:

1. Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Università di Pavia

2. Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100, Siena

3. Servizio di Analisi Microbiologiche I.R.C.C.S. S. Matteo, I-27100, Pavia

4. Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100, L'Aquila, Italy

Abstract

ABSTRACT β-Lactamase production was detected in 147 (52%) of 282 consecutive nonduplicate Proteus mirabilis isolates obtained over a 1-year period from the S. Matteo Hospital of Pavia (northern Italy). Seventy isolates (48% of the β-lactamase producers) were found to produce extended-spectrum β-lactamases (ESBLs), identified as PER-1 (first report in this species) and TEM-52 in 52 and 18 isolates, respectively. Analysis of clonal diversity of the ESBL producers suggested different spreading patterns for the two ESBL determinants.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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