TEM-72, a New Extended-Spectrum β-Lactamase Detected in Proteus mirabilis and Morganella morganii in Italy-Reference-Cited by-同舟云学术

TEM-72, a New Extended-Spectrum β-Lactamase Detected in Proteus mirabilis and Morganella morganii in Italy

Published:2000-09 Issue:9 Volume:44 Page:2537-2539
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Perilli Mariagrazia¹,Segatore Bernardetta¹,Rosaria De Massis Maria¹,Riccio Maria Letizia²,Bianchi Ciro³,Zollo Alessandro³,Rossolini Gian Maria²,Amicosante Gianfranco¹

Affiliation:

1. Dipartimento di Scienze e Tecnologie Biomediche, Cattedra di Enzimologia, Università di L'Aquila, L'Aquila,1

2. Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Siena,2 and

3. Dipartimento Medico Wyeth-Lederle Italia S.p.A., Aprilia,3 Italy

Abstract

ABSTRACT A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of bla TEM-72 in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.9.2537-2539.2000

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