Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance-Reference-Cited by-同舟云学术

Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance

Published:2023-06-15 Issue:6 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kordalewska Milena¹^ORCID,Cancino-Prado Geselle¹,Nobrega de Almeida Júnior João²³^ORCID,Brasil Brandão Igor⁴,Tigulini de Souza Peral Renata⁵,Colombo Arnaldo L.²,Perlin David S.¹^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil

3. Hospital Israelita Albert Einstein, São Paulo, Brazil

4. Hospital da Bahia, Salvador, Brazil

5. Brazilian Ministry of Health, Brasília, Brazil

Abstract

We determined the echinocandin susceptibility and FKS1 genotypes of 13 clinical isolates of Candida auris that were recovered from 4 patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant, and they harbored a novel FKS1 mutation that led to an amino acid change W691L located downstream from hot spot 1.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00423-23

Reference21 articles.

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