Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to <i>FKS1</i> Mutations-Reference-Cited by-同舟云学术

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hirayama Tatsuro¹²^ORCID,Miyazaki Taiga³,Sumiyoshi Makoto³,Ito Yuya²,Ashizawa Nobuyuki²⁴,Takeda Kazuaki²,Iwanaga Naoki²,Takazono Takahiro²⁵^ORCID,Yamamoto Kazuko²,Izumikawa Koichi⁴⁵,Yanagihara Katsunori⁶,Makimura Koichi⁷,Tsukamoto Kazuhiro¹,Kohno Shigeru²,Mukae Hiroshi²

Affiliation:

1. Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

2. Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan

3. Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

4. Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan

5. Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

6. Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, Japan

7. Teikyo University Institute of Medical Mycology, Teikyo University, Tokyo, Japan

Abstract

Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01243-22

Reference20 articles.

1. Approach to the Investigation and Management of Patients With Candida auris, an Emerging Multidrug-Resistant Yeast

2. A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance