Case Commentary: Extending our therapeutic range against multidrug-resistant <i>Candida</i>-Reference-Cited by-同舟云学术

Case Commentary: Extending our therapeutic range against multidrug-resistant Candida

Published:2024-08-07 Issue:8 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adelman Max W.¹²³⁴^ORCID,Andes David R.⁵^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA

2. Center for Infectious Diseases, Houston Methodist Research Institute, Houston, Texas, USA

3. Division of Pulmonary, Critical Care, and Sleep, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA

4. Weill Cornell Medicine, New York, New York, USA

5. Division of Infectious Diseases, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

Abstract

ABSTRACT Deep-seated Candida spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024, https://doi.org/10.1128/aac.00750-24 ) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant Candida spp. infections.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Houston Methodist Hospital | Houston Methodist Research Institute

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00847-24

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