Affiliation:
1. Departments of Biology
2. Clinical Development, Optimer Pharmaceuticals, Inc., San Diego, California
Abstract
ABSTRACT
The effects of the inoculum, pH, cation concentrations, and different lots of commercial media on the
in vitro
susceptibility of
Clostridium difficile
to fidaxomicin were examined. Of the factors evaluated, only pH alterations influenced the activity of fidaxomicin against
C. difficile
, noticeably reducing its activity at higher pH (≥7.9).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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