Affiliation:
1. Departments of Biology
2. Clinical Development, Optimer Pharmaceuticals, Inc., San Diego, California
Abstract
ABSTRACT
The effects of the inoculum, pH, cation concentrations, and different lots of commercial media on the
in vitro
susceptibility of
Clostridium difficile
to fidaxomicin were examined. Of the factors evaluated, only pH alterations influenced the activity of fidaxomicin against
C. difficile
, noticeably reducing its activity at higher pH (≥7.9).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference21 articles.
1. In Vitro Activity of OPT-80 against
Clostridium difficile
2. Archibald, L. K., S. N. Banerjee, and W. R. Jarvis. 2004. Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001. J. Infect. Dis.189:1585-1589.
3. Bauer, M. P., A. Goorhuis, T. Koster, S. C. Numan-Ruberg, E. C. Hagen, S. B. Debast, E. J. Kuijper, and J. T. van Dissel. 2008. Community-onset Clostridium difficile-associated diarrhoea not associated with antibiotic usage—two case reports with review of the changing epidemiology of Clostridium difficile-associated diarrhoea. Neth. J. Med.66:207-211.
4. Effect of medium, pH, and inoculum size on activity of ceftizoxime and Sch-34343 against anaerobic bacteria
5. Cohen, M. B. 2009. Clostridium difficile infections: emerging epidemiology and new treatments. J. Pediatr. Gastroenterol. Nutr.48(Suppl.):S63-S65.
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献