Formal Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity-Reference-Cited by-同舟云学术

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Formal Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity

Published:2024-05-21 Issue:6 Volume:4 Page:2267-2280
ISSN:2691-3704
Container-title:JACS Au
language:en
Short-container-title:JACS Au

Author:

Ferrara Isabella¹^ORCID,Chesnokov Gleb A.¹,Dittmann Silvia²,Blacque Olivier¹,Sievers Susanne²,Gademann Karl¹^ORCID

Affiliation:

1. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland

2. Department for Microbial Physiology and Molecular Biology, Institute of Microbiology, Center for Functional Genomics of Microbes, University of Greifswald, Felix-Hausdorff-Strasse 8, 17489 Greifswald, Germany

Funder

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacsau.4c00206

Reference70 articles.

1. The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry–Biology Interface

2. Single-atom logic for heterocycle editing

3. Fluorine in medicinal chemistry

4. Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

5. Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

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