Affiliation:
1. Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, 04103 Leipzig, Germany
Abstract
ABSTRACT
Clostridium difficile
remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of
C. difficile
to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207
C. difficile
strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all
C. difficile
strains tested.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
93 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献