Affiliation:
1. Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
2. Department of Medicine, University of Illinois, Chicago, Illinois 60612
Abstract
ABSTRACT
The prevalence of extended-spectrum β-lactamase-producing strains was demonstrated in 5 of 44 (11.4%)
Escherichia coli
, 17 of 43 (39.5%)
Klebsiella pneumoniae
, 3 of 50 (6.0%)
Enterobacter cloacae
, and 2 of 25 (8.0%)
Citrobacter freundii
strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 β-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
70 articles.
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