bla CTX-M-2 Is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513-Reference-Cited by-同舟云学术

bla CTX-M-2 Is Located in an Unusual Class 1 Integron (In35) Which Includes Orf513

Published:2002-07 Issue:7 Volume:46 Page:2303-2306
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arduino Sonia M.¹,Roy Paul H.²,Jacoby George A.³,Orman Betina E.¹,Pineiro Silvia A.¹,Centron Daniela¹

Affiliation:

1. Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina

2. Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec G1K 7P4, and Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, Sainte-Foy, Québec G1V 4G2, Canada

3. Edith Nourse Rogers Memorial Veterans Hospital, Bedford, and Lahey Clinic, Burlington, Massachusetts

Abstract

ABSTRACT Examination of the bla CTX-M-2 gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla KLUA-1 gene, are located in a complex sul1 -type integron, termed In35, that includes Orf513. It is possible that bla CTX-M-2 was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.7.2303-2306.2002

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