Affiliation:
1. Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523
Abstract
ABSTRACT
We have developed a rapid new in vivo method for screening experimental drugs for their activity against
Mycobacterium tuberculosis
by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of active compounds can be seen after only 8 days of treatment. To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference19 articles.
1. Burman, W. J. 1997. The value of in vitro drug activity and pharmacokinetics in predicting the effectiveness of antimicrobial therapy: a critical review. Am. J. Med. Sci.313:355-363.
2. Canetti, G., F. Grumbach, and J. Grosset. 1963. Long-term, two-stage chemotherapy of advanced experimental murine tuberculosis with intermittent regimens during the second stage. Tubercle44:236-240.
3. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon-γ gene-disrupted mice. J. Exp. Med.178:2243-2247.
4. Activities of Several Novel Oxazolidinones against
Mycobacterium tuberculosis
in a Murine Model
5. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science259:1739-1742.
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