Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species-Reference-Cited by-同舟云学术

Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species

Published:2022-09-20 Issue:9 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shee Somnath¹²,Singh Samsher¹²^ORCID,Tripathi Ashutosh¹²,Thakur Chandrani³,Kumar T Anand⁴,Das Mayashree¹²,Yadav Vikas¹²,Kohli Sakshi¹²,Rajmani Raju S.²,Chandra Nagasuma³^ORCID,Chakrapani Harinath⁴,Drlica Karl⁵,Singh Amit¹²^ORCID

Affiliation:

1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India

2. Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, Karnataka, India

3. Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, India

4. Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune, Maharashtra, India

5. Public Health Research Institute and Department of Microbiology, Biochemistry & Molecular Genetics, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA

Abstract

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin on the Mycobacterium tuberculosis redox state were explored to identify strategies for increasing lethality and reducing the prevalence of extensively resistant tuberculosis.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

The Wellcome Trust DBT India Alliance

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00592-22

Reference111 articles.

1. Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment

2. WHO. 2019. Global tuberculosis report 2019. World Health Organization, Geneva, Switzerland.