PML Alternative Splice Products Differentially Regulate HAdV Productive Infection-Reference-Cited by-同舟云学术

PML Alternative Splice Products Differentially Regulate HAdV Productive Infection

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mai Julia¹²,Stubbe Miona²,Hofmann Samuel¹²,Masser Sawinee¹,Dobner Thomas³,Boutell Christopher⁴,Groitl Peter²,Schreiner Sabrina¹²⁵⁶

Affiliation:

1. Institute of Virology, Hannover Medical School, Hannover, Germany

2. Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany

3. Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany

4. MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, Scotland, United Kingdom

5. Institute of Virology, Helmholtz Zentrum München, Munich, Germany

6. Cluster of Excellence RESIST (Resolving Infection Susceptibility; EXC 2155), Hannover Medical School, Hannover, Germany

Abstract

Actual work provides evidence that PML-NB-associated factors might also be beneficial for distinct viral processes indicating why genomes and replication centers of nuclear replicating viruses are often found juxtaposed to PML-NBs. Alternatively spliced PML isoforms I-VII are expressed from one single pml gene containing nine exons and their transcription is tightly controlled and stimulated by interferons and p53.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00785-22

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