Strong Increase in Moxifloxacin Resistance Rate among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China, 2007 to 2013

Author:

Xia Hui1,Zheng Yang1,Liu Dongxin2,Wang Shengfen1,He WenCong1,Zhao Bing1,Song Yuanyuan1,Ou Xichao1,Zhou Yang1,van den Hof Susan3,Cobelens Frank4,Zhao YanLin1ORCID

Affiliation:

1. National Tuberculosis Reference Laboratory, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

2. Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen, China

3. National Institute of Public Health and the Environment, Centre for Infectious Disease Epidemiology and Surveillance, Bilthoven, The Netherlands

4. Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands

Abstract

China is one of the high-burden countries for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). Moxifloxacin is one of the critical antituberculosis drugs for MDR/RR-TB treatment.

Funder

National Science and Technology Major Project of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference47 articles.

1. World Health Organization. 2020. Global tuberculosis report 2020. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2020. WHO consolidated guidelines on tuberculosis. Module 4: treatment – drug-resistant tuberculosis treatment. World Health Organization, Geneva, Switzerland.

3. National Survey of Drug-Resistant Tuberculosis in China

4. Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment

5. Stepwise Decrease in Moxifloxacin Susceptibility amongst Clinical Isolates of Multidrug-ResistantMycobacterium tuberculosis:Correlation with Ofloxacin Susceptibility

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