Distribution and Spread of the Mobilized RND Efflux Pump Gene Cluster <i>tmexCD-toprJ</i> in Klebsiella pneumoniae from Different Sources-Reference-Cited by-同舟云学术

Distribution and Spread of the Mobilized RND Efflux Pump Gene Cluster tmexCD-toprJ in Klebsiella pneumoniae from Different Sources

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Lin¹²,Wang Hanyun¹,Meng Nan¹,Wang Zhenyu¹,Li Guiling³⁴,Jiao Xinan¹²^ORCID,Wang Jing¹²^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China

2. Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China

3. Department of Laboratory Medicine, Clinical Medical College, Yangzhou University, Yangzhou, China

4. Clinical Testing Center, Northern Jiangsu People’s Hospital, Yangzhou, China

Abstract

Tigecycline has been regarded as one of the last-resort antibiotics available for the treatment of infections caused by carbapenem-resistant Enterobacterales . The plasmid-mediated resistance-nodulation-division–type efflux pump gene cluster tmexCD - toprJ is a newly identified tigecycline resistance determinant.

Funder

Postgraduate Research & Practice Innovation Program of Jiangsu Province

The fifth phase of the “333 project” scientific research project in Jiangsu Province

The Priority Academic Program Development of Jiangsu Higher Education Institution

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05364-22

Reference12 articles.

1. The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace