Emergence of a Novel Plasmid-Mediated Tigecycline Resistance Gene Cluster, <i>tmexCD4-toprJ4</i> , in Klebsiella quasipneumoniae and Enterobacter <i>roggenkampii</i>-Reference-Cited by-同舟云学术

Emergence of a Novel Plasmid-Mediated Tigecycline Resistance Gene Cluster, tmexCD4-toprJ4 , in Klebsiella quasipneumoniae and Enterobacter roggenkampii

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Gao Xun¹,Wang Chengzhen¹,Lv Luchao¹,He Xiaotong¹,Cai Zhongpeng¹,He Wanyun¹,Li Tong¹,Liu Jian-Hua¹²^ORCID

Affiliation:

1. College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, National Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in Animals, Guangzhou, China

2. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China

Abstract

The plasmid-mediated tigecycline resistance gene cluster tmexCD1-toprJ1 and other variants have been detected in a variety of strains from multiple sources, including human-derived strains. In addition to tigecycline, these tmexCD-toprJ -like gene clusters reduce susceptibility of the host strain to many other antimicrobials.

Funder

the Laboratory of Lingnan Modern Agriculture Project

the Nation Nature Science Foundation of China

the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01094-22

Reference18 articles.

1. Efficacy and safety of tigecycline for the treatment of infectious diseases: a meta-analysis