A Novel Transferable Resistance-Nodulation-Division Pump Gene Cluster, tmexCD2-toprJ2 , Confers Tigecycline Resistance in Raoultella ornithinolytica-Reference-Cited by-同舟云学术

A Novel Transferable Resistance-Nodulation-Division Pump Gene Cluster, tmexCD2-toprJ2 , Confers Tigecycline Resistance in Raoultella ornithinolytica

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Cheng-Zhen¹²,Gao Xun¹²,Yang Qi-Wen³,Lv Lu-Chao¹²,Wan Miao¹²,Yang Jun¹²,Cai Zhong-Peng¹²,Liu Jian-Hua¹²^ORCID

Affiliation:

1. College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, National Risk Assessment Laboratory for Antimicrobial Resistance of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

2. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China

3. Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

Abstract

We recently identified a novel plasmid-mediated resistance-nodulation-division (RND)-type efflux pump gene cluster, tmexCD1-toprJ1 , in Klebsiella pneumoniae that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their functions and transfer mechanisms remain unknown.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02229-20

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