l -Valine Production during Growth of Pyruvate Dehydrogenase Complex- Deficient Corynebacterium glutamicum in the Presence of Ethanol or by Inactivation of the Transcriptional Regulator SugR-Reference-Cited by-同舟云学术

l -Valine Production during Growth of Pyruvate Dehydrogenase Complex- Deficient Corynebacterium glutamicum in the Presence of Ethanol or by Inactivation of the Transcriptional Regulator SugR

Published:2009-02-15 Issue:4 Volume:75 Page:1197-1200
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Blombach Bastian¹,Arndt Annette¹,Auchter Marc¹,Eikmanns Bernhard J.¹

Affiliation:

1. Institute of Microbiology and Biotechnology, University of Ulm, D-89069 Ulm, Germany

Abstract

ABSTRACT Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce l -valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient l -valine production.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02351-08

Reference17 articles.

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2. The Alcohol Dehydrogenase Gene adhA in Corynebacterium glutamicum Is Subject to Carbon Catabolite Repression

3. l -Valine Production with Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum

4. Blombach, B., M. E. Schreiner, M. Moch, M. Oldiges, and B. J. Eikmanns. 2007. Effect of pyruvate dehydrogenase complex deficiency on l-lysine production with Corynebacterium glutamicum. Appl. Microbiol. Biotechnol.76:615-623.

5. Blombach, B., M. E. Schreiner, T. Bartek, M. Oldiges, and B. J. Eikmanns. 2008. Corynebacterium glutamicum tailored for high-yield l-valine production. Appl. Microbiol. Biotechnol.79:471-479.

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