Microbial Unmasking of Plant Glycosides-Reference-Cited by-同舟云学术

Microbial Unmasking of Plant Glycosides

Published:2018-03-07 Issue:1 Volume:9 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Biernat Kristen A.¹,Li Bo¹,Redinbo Matthew R.¹²³⁴

Affiliation:

1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Department of Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Integrative Program for Biological & Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

ABSTRACT The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio , M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17 ) describe how one gut microbe, Lactobacillus acidophilus , catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.

Funder

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02433-17

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