Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2-Reference-Cited by-同舟云学术

Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ruiz-Rodriguez Paula¹^ORCID,Francés-Gómez Clara¹^ORCID,Chiner-Oms Álvaro²,López Mariana G.²,Jiménez-Serrano Santiago²,Cancino-Muñoz Irving²,Ruiz-Hueso Paula³,Torres-Puente Manuela²,Bracho Maria Alma¹⁴,D’Auria Giuseppe¹³⁴,Martinez-Priego Llúcia³,Guerreiro Manuel⁵⁶,Montero-Alonso Marta⁷,Gómez María Dolores⁸,Piñana José Luis⁹,González-Candelas Fernando¹⁴,Comas Iñaki²⁴^ORCID,Marina Alberto²¹⁰^ORCID,Geller Ron¹^ORCID,Coscolla Mireia¹^ORCID,

Affiliation:

1. I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain

2. Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain

3. Sequencing and Bioinformatics Service of Valencian Region Foundation for the Promotion of Health and Biomedical Research, Valencia, Spain

4. CIBER in Epidemiology and Public Health, Madrid, Spain

5. Hematology Department, Hospital Universitari i Politècnic la Fe, Valencia, Spain

6. Instituto de Investigación Sanitaria La Fe, Valencia, Spain

7. Infectious Diseases Unit, Hospital Universitari i Politècnic la Fe, Valencia, Spain

8. Microbiology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain

9. Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain

10. CIBER in Rare Diseases, Madrid, Spain

Abstract

We observed repeated, independent emergence of mutations in the SARS-CoV-2 spike involving amino acids 1163 and 1167, within the HR2 functional motif. Conclusions derived from evolutionary and genomic diversity analysis suggest that the co-occurrence of both mutations might pose an advantage for the virus and therefore a threat to effective control of the epidemic.

Funder

European Commission-NextGenerationEU

Ministerio de Ciencia, Innovación y Universidades

MEC | Instituto de Salud Carlos III

GVA | Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana

MEC | Consejo Superior de Investigaciones Científicas

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02315-21