Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Author:

Volz ErikORCID,Hill VerityORCID,McCrone John T.ORCID,Price AnnaORCID,Jorgensen DavidORCID,O’Toole Áine,Southgate JoelORCID,Johnson RobertORCID,Jackson Ben,Nascimento Fabricia F.,Rey Sara M.ORCID,Nicholls Samuel M.ORCID,Colquhoun Rachel M.ORCID,da Silva Filipe AnaORCID,Shepherd JamesORCID,Pascall David J.ORCID,Shah RajivORCID,Jesudason NatashaORCID,Li KathyORCID,Jarrett RuthORCID,Pacchiarini NicoleORCID,Bull MatthewORCID,Geidelberg Lily,Siveroni Igor,Goodfellow Ian,Loman Nicholas J.,Pybus Oliver G.ORCID,Robertson David L.ORCID,Thomson Emma C.ORCID,Rambaut Andrew,Connor Thomas R.ORCID,Koshy Cherian,Wise Emma,Cortes Nick,Lynch Jessica,Kidd Stephen,Mori Matilde,Fairley Derek J.,Curran Tanya,McKenna James P.,Adams Helen,Fraser Christophe,Golubchik Tanya,Bonsall David,Moore Catrin,Caddy Sarah L.,Khokhar Fahad A.,Wantoch Michelle,Reynolds Nicola,Warne Ben,Maksimovic Joshua,Spellman Karla,McCluggage Kathryn,John Michaela,Beer Robert,Afifi Safiah,Morgan Sian,Marchbank Angela,Price Anna,Kitchen Christine,Gulliver Huw,Merrick Ian,Southgate Joel,Guest Martyn,Munn Robert,Workman Trudy,Connor Thomas R.,Fuller William,Bresner Catherine,Snell Luke B.,Charalampous Themoula,Nebbia Gaia,Batra Rahul,Edgeworth Jonathan,Robson Samuel C.,Beckett Angela,Loveson Katie F.,Aanensen David M.,Underwood Anthony P.,Yeats Corin A.,Abudahab Khalil,Taylor Ben E.W.,Menegazzo Mirko,Clark Gemma,Smith Wendy,Khakh Manjinder,Fleming Vicki M.,Lister Michelle M.,Howson-Wells Hannah C.,Berry Louise,Boswell Tim,Joseph Amelia,Willingham Iona,Bird Paul,Helmer Thomas,Fallon Karlie,Holmes Christopher,Tang Julian,Raviprakash Veena,Campbell Sharon,Sheriff Nicola,Loose Matthew W.,Holmes Nadine,Moore Christopher,Carlile Matthew,Wright Victoria,Sang Fei,Debebe Johnny,Coll Francesc,Signell Adrian W.,Betancor Gilberto,Wilson Harry D.,Feltwell Theresa,Houldcroft Charlotte J.,Eldirdiri Sahar,Kenyon Anita,Davis Thomas,Pybus Oliver,du Plessis Louis,Zarebski Alex,Raghwani Jayna,Kraemer Moritz,Francois Sarah,Attwood Stephen,Vasylyeva Tetyana,Torok M. Estee,Hamilton William L.,Goodfellow Ian G.,Hall Grant,Jahun Aminu S.,Chaudhry Yasmin,Hosmillo Myra,Pinckert Malte L.,Georgana Iliana,Yakovleva Anna,Meredith Luke W.,Moses Samuel,Lowe Hannah,Ryan Felicity,Fisher Chloe L.,Awan Ali R.,Boyes John,Breuer Judith,Harris Kathryn Ann,Brown Julianne Rose,Shah Divya,Atkinson Laura,Lee Jack C.D.,Alcolea-Medina Adela,Moore Nathan,Cortes Nicholas,Williams Rebecca,Chapman Michael R.,Levett Lisa J.,Heaney Judith,Smith Darren L.,Bashton Matthew,Young Gregory R.,Allan John,Loh Joshua,Randell Paul A.,Cox Alison,Madona Pinglawathee,Holmes Alison,Bolt Frances,Price James,Mookerjee Siddharth,Rowan Aileen,Taylor Graham P.,Ragonnet-Cronin Manon,Nascimento Fabricia F.,Jorgensen David,Siveroni Igor,Johnson Rob,Boyd Olivia,Geidelberg Lily,Volz Erik M.,Brunker Kirstyn,Smollett Katherine L.,Loman Nicholas J.,Quick Joshua,McMurray Claire,Stockton Joanne,Nicholls Sam,Rowe Will,Poplawski Radoslaw,Martinez-Nunez Rocio T.,Mason Jenifer,Robinson Trevor I.,O'Toole Elaine,Watts Joanne,Breen Cassie,Cowell Angela,Ludden Catherine,Sluga Graciela,Machin Nicholas W.,Ahmad Shazaad S.Y.,George Ryan P.,Halstead Fenella,Sivaprakasam Venkat,Thomson Emma C.,Shepherd James G.,Asamaphan Patawee,Niebel Marc O.,Li Kathy K.,Shah Rajiv N.,Jesudason Natasha G.,Parr Yasmin A.,Tong Lily,Broos Alice,Mair Daniel,Nichols Jenna,Carmichael Stephen N.,Nomikou Kyriaki,Aranday-Cortes Elihu,Johnson Natasha,Starinskij Igor,da Silva Filipe Ana,Robertson David L.,Orton Richard J.,Hughes Joseph,Vattipally Sreenu,Singer Joshua B.,Hale Antony D.,Macfarlane-Smith Louissa R.,Harper Katherine L.,Taha Yusri,Payne Brendan A.I.,Burton-Fanning Shirelle,Waugh Sheila,Collins Jennifer,Eltringham Gary,Templeton Kate E.,McHugh Martin P.,Dewar Rebecca,Wastenge Elizabeth,Dervisevic Samir,Stanley Rachael,Prakash Reenesh,Stuart Claire,Elumogo Ngozi,Sethi Dheeraj K.,Meader Emma J.,Coupland Lindsay J.,Potter Will,Graham Clive,Barton Edward,Padgett Debra,Scott Garren,Swindells Emma,Greenaway Jane,Nelson Andrew,Yew Wen C.,Resende Silva Paola C.,Andersson Monique,Shaw Robert,Peto Timothy,Justice Anita,Eyre David,Crooke Derrick,Hoosdally Sarah,Sloan Tim J.,Duckworth Nichola,Walsh Sarah,Chauhan Anoop J.,Glaysher Sharon,Bicknell Kelly,Wyllie Sarah,Butcher Ethan,Elliott Scott,Lloyd Allyson,Impey Robert,Levene Nick,Monaghan Lynn,Bradley Declan T.,Allara Elias,Pearson Clare,Muir Peter,Vipond Ian B.,Hopes Richard,Pymont Hannah M.,Hutchings Stephanie,Curran Martin D.,Parmar Surendra,Lackenby Angie,Mbisa Tamyo,Platt Steven,Miah Shahjahan,Bibby David,Manso Carmen,Hubb Jonathan,Chand Meera,Dabrera Gavin,Ramsay Mary,Bradshaw Daniel,Thornton Alicia,Myers Richard,Schaefer Ulf,Groves Natalie,Gallagher Eileen,Lee David,Williams David,Ellaby Nicholas,Harrison Ian,Hartman Hassan,Manesis Nikos,Patel Vineet,Bishop Chloe,Chalker Vicki,Osman Husam,Bosworth Andrew,Robinson Esther,Holden Matthew T.G.,Shaaban Sharif,Birchley Alec,Adams Alexander,Davies Alisha,Gaskin Amy,Plimmer Amy,Gatica-Wilcox Bree,McKerr Caoimhe,Moore Catherine,Williams Chris,Heyburn David,De Lacy Elen,Hilvers Ember,Downing Fatima,Shankar Giri,Jones Hannah,Asad Hibo,Coombes Jason,Watkins Joanne,Evans Johnathan M.,Fina Laia,Gifford Laura,Gilbert Lauren,Graham Lee,Perry Malorie,Morgan Mari,Bull Matthew,Cronin Michelle,Pacchiarini Nicole,Craine Noel,Jones Rachel,Howe Robin,Corden Sally,Rey Sara,Kumziene-Summerhayes Sara,Taylor Sarah,Cottrell Simon,Jones Sophie,Edwards Sue,O’Grady Justin,Page Andrew J.,Wain John,Webber Mark A.,Mather Alison E.,Baker David J.,Rudder Steven,Yasir Muhammad,Thomson Nicholas M.,Aydin Alp,Tedim Ana P.,Kay Gemma L.,Trotter Alexander J.,Gilroy Rachel A.J.,Alikhan Nabil-Fareed,de Oliveira Martins Leonardo,Le-Viet Thanh,Meadows Lizzie,Kolyva Anastasia,Diaz Maria,Bell Andrew,Gutierrez Ana Victoria,Charles Ian G.,Adriaenssens Evelien M.,Kingsley Robert A.,Casey Anna,Simpson David A.,Molnar Zoltan,Thompson Thomas,Acheson Erwan,Masoli Jane A.H.,Knight Bridget A.,Hattersley Andrew,Ellard Sian,Auckland Cressida,Mahungu Tabitha W.,Irish-Tavares Dianne,Haque Tanzina,Bourgeois Yann,Scarlett Garry P.,Partridge David G.,Raza Mohammad,Evans Cariad,Johnson Kate,Liggett Steven,Baker Paul,Essex Sarah,Lyons Ronan A.,Caller Laura G.,Castellano Sergi,Williams Rachel J.,Kristiansen Mark,Roy Sunando,Williams Charlotte A.,Dyal Patricia L.,Tutill Helena J.,Panchbhaya Yasmin N.,Forrest Leysa M.,Niola Paola,Findlay Jacqueline,Brooks Tony T.,Gavriil Artemis,Mestek-Boukhibar Lamia,Weeks Sam,Pandey Sarojini,Berry Lisa,Jones Katie,Richter Alex,Beggs Andrew,Smith Colin P.,Bucca Giselda,Hesketh Andrew R.,Harrison Ewan M.,Peacock Sharon J.,Palmer Sophie,Churcher Carol M.,Bellis Katherine L.,Girgis Sophia T.,Naydenova Plamena,Blane Beth,Sridhar Sushmita,Ruis Chris,Forrest Sally,Cormie Claire,Gill Harmeet K.,Dias Joana,Higginson Ellen E.,Maes Mailis,Young Jamie,Kermack Leanne M.,Hadjirin Nazreen F.,Aggarwal Dinesh,Griffith Luke,Swingler Tracey,Davidson Rose K.,Rambaut Andrew,Williams Thomas,Balcazar Carlos E.,Gallagher Michael D.,O'Toole Áine,Rooke Stefan,Jackson Ben,Colquhoun Rachel,Ashworth Jordan,Hill Verity,McCrone J.T.,Scher Emily,Yu Xiaoyu,Williamson Kathleen A.,Stanton Thomas D.,Michell Stephen L.,Bewshea Claire M.,Temperton Ben,Michelsen Michelle L.,Warwick-Dugdale Joanna,Manley Robin,Farbos Audrey,Harrison James W.,Sambles Christine M.,Studholme David J.,Jeffries Aaron R.,Darby Alistair C.,Hiscox Julian A.,Paterson Steve,Iturriza-Gomara Miren,Jackson Kathryn A.,Lucaci Anita O.,Vamos Edith E.,Hughes Margaret,Rainbow Lucille,Eccles Richard,Nelson Charlotte,Whitehead Mark,Turtle Lance,Haldenby Sam T.,Gregory Richard,Gemmell Matthew,Kwiatkowski Dominic,de Silva Thushan I.,Smith Nikki,Angyal Adrienn,Lindsey Benjamin B.,Groves Danielle C.,Green Luke R.,Wang Dennis,Freeman Timothy M.,Parker Matthew D.,Keeley Alexander J.,Parsons Paul J.,Tucker Rachel M.,Brown Rebecca,Wyles Matthew,Constantinidou Chrystala,Unnikrishnan Meera,Ott Sascha,Cheng Jeffrey K.J.,Bridgewater Hannah E.,Frost Lucy R.,Taylor-Joyce Grace,Stark Richard,Baxter Laura,Alam Mohammad T.,Brown Paul E.,McClure Patrick C.,Chappell Joseph G.,Tsoleridis Theocharis,Ball Jonathan,Gramatopoulos Dimitris,Buck David,Todd John A.,Green Angie,Trebes Amy,MacIntyre-Cockett George,de Cesare Mariateresa,Langford Cordelia,Alderton Alex,Amato Roberto,Goncalves Sonia,Jackson David K.,Johnston Ian,Sillitoe John,Palmer Steve,Lawniczak Mara,Berriman Matt,Danesh John,Livett Rich,Shirley Lesley,Farr Ben,Quail Mike,Thurston Scott,Park Naomi,Betteridge Emma,Weldon Danni,Goodwin Scott,Nelson Rachel,Beaver Charlotte,Letchford Laura,Jackson David A.,Foulser Luke,McMinn Liz,Prestwood Liam,Kay Sally,Kane Leanne,Dorman Matthew J.,Martincorena Inigo,Puethe Christoph,Keatley Jon-Paul,Tonkin-Hill Gerry,Smith Christen,Jamrozy Dorota,Beale Mathew A.,Patel Minal,Ariani Cristina,Spencer-Chapman Michael,Drury Eleanor,Lo Stephanie,Rajatileka Shavanthi,Scott Carol,James Keith,Buddenborg Sarah K.,Berger Duncan J.,Patel Gaurang,Garcia-Casado Maria V.,Dibling Thomas,McGuigan Samantha,Rogers Hazel A.,Hunter Adam D.,Souster Emily,Neaverson Alexandra S.

Funder

Biotechnology and Biological Sciences Research Council

European Commission

Wellcome Trust

Medical Research Council

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference54 articles.

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