Author:
Cuzon Gaelle,Naas Thierry,Nordmann Patrice
Abstract
ABSTRACTThe carbapenemase geneblaKPC, which is rapidly spreading worldwide, is located on a Tn3-based transposon, Tn4401. In a transposition-conjugation assay, Tn4401was able to mobilizeblaKPC-2gene at a frequency of 4.4 × 10−6/recipient cell. A 5-bp target site duplication was evidenced upon each insertion without target site specificity. This study demonstrated that Tn4401is an active transposon capable of mobilizingblaKPCgenes at high frequency.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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