Dissemination ofblaKPC-2by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae Species in Brazil

Abstract

ABSTRACTThis article reports the spread ofblaKPC-2in the Sao Paulo and Rio de Janeiro states, facilitated by globally spreadK. pneumoniaeclonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of theEnterobacteriaceae(Enterobacter cloacae,Serratia marcescens, andCitrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.