Capsule Shields the Function of Short Bacterial Adhesins-Reference-Cited by-同舟云学术

Capsule Shields the Function of Short Bacterial Adhesins

Published:2004-03 Issue:5 Volume:186 Page:1249-1257
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Schembri Mark A.¹,Dalsgaard Dorte¹,Klemm Per¹

Affiliation:

1. Microbial Adhesion Group, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark

Abstract

ABSTRACT Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding. The phenomenon is not restricted to Escherichia coli but can occur in other gram-negative bacteria. Likewise, we show that other short adhesins exemplified by the AIDA-I protein are blocked by the presence of a capsule. The results support the notion that capsule polysaccharides sterically prevent receptor-target recognition of short bacterial adhesins. This negative interference has important biological consequences, such as affecting the ability of bacteria to form biofilms.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.186.5.1249-1257.2004

Reference53 articles.

1. Anderson, G. G., J. J. Palermo, J. D. Schilling, R. Roth, J. Heuser, and S. J. Hultgren. 2003. Intracellular bacterial biofilm-like pods in urinary tract infections. Science301:105-107.

2. Bachmann B. 1996. Derivations and genotypes of some mutant derivatives of Escherichia coli K-12 p. 2460-2488. In F. C. Neidhardt et al. (ed.) Escherichia coli and Salmonella : cellular and molecular biology 2nd ed. ASM Press Washington D.C.

3. Bacon, D. J., C. M. Szymanski, D. H. Burr, R. P. Silver, R. A. Alm, and P. Guerry. 2001. A phase variable capsule is involved in virulence of Campylobacter jejuni 81-176. Mol. Microbiol.40:769-777.

4. Cloning and expression of an adhesin (AIDA-I) involved in diffuse adherence of enteropathogenic Escherichia coli

5. Benz, I., and M. A. Schmidt. 1992. AIDA-I, the adhesin involved in diffuse adherence of the diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is synthesized via a precursor molecule. Mol. Microbiol.6:1539-1546.

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