Single-Cell Transcriptomics Reveal a Correlation between Genome Architecture and Gene Family Evolution in Ciliates-Reference-Cited by-同舟云学术

Single-Cell Transcriptomics Reveal a Correlation between Genome Architecture and Gene Family Evolution in Ciliates

Published:2019-12-24 Issue:6 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Yan Ying¹^ORCID,Maurer-Alcalá Xyrus X.¹²^ORCID,Knight Rob³⁴⁵^ORCID,Kosakovsky Pond Sergei L.⁶^ORCID,Katz Laura A.¹²^ORCID

Affiliation:

1. Smith College, Department of Biological Sciences, Northampton, Massachusetts, USA

2. University of Massachusetts Amherst, Program in Organismic and Evolutionary Biology, Amherst, Massachusetts, USA

3. University of California San Diego, Department of Pediatrics, San Diego, California, USA

4. University of California San Diego, Department of Computer Science and Engineering, San Diego, California, USA

5. University of California San Diego, Center for Microbiome Innovation, San Diego, California, USA

6. Temple University, Institute for Genomics and Evolutionary Medicine, Philadelphia, Pennsylvania, USA

Abstract

Ciliates, a eukaryotic clade that is over 1 billion years old, are defined by division of genome function between transcriptionally inactive germline micronuclei and functional somatic macronuclei. To date, most analyses of gene family evolution have been limited to cultivable model lineages (e.g., Tetrahymena , Paramecium , Oxytricha , and Stylonychia ). Here, we focus on the uncultivable Karyorelictea and its understudied sister class Heterotrichea, which represent two extremes in genome architecture.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02524-19

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