Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression-Reference-Cited by-同舟云学术

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Published:2019-02 Issue:2 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ranjitkar Srijan¹,Jones Adriana K.¹,Mostafavi Mina¹,Zwirko Zachary²,Iartchouk Oleg²,Barnes S. Whitney³,Walker John R.³,Willis Thomas W.¹,Lee Patrick S.¹,Dean Charles R.¹^ORCID

Affiliation:

1. Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA

2. Biotherapeutic and Analytical Technologies, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA

3. Genomics Institute of Novartis Research Foundation (GNF), San Diego, California, USA

Abstract

Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01718-18

Reference74 articles.

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4. Enhanced annotations and features for comparing thousands ofPseudomonasgenomes in the Pseudomonas genome database

5. Influence of Mutations in the mexR Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System of Pseudomonas aeruginosa

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