Affiliation:
1. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada
Abstract
ABSTRACT
Several
nalB
-type multidrug-resistant mutants of
Pseudomonas aeruginosa
overexpressed MexAB-OprM and carried mutations in the local regulatory gene,
mexR
. Others, dubbed
nalC
types, carried mutations elsewhere and overexpressed MexAB-OprM less extensively than the
nalB
strains. Available evidence showed that MexR acted solely as repressor. Disruption of the
mexR
gene at various places suggested that the 5′ end of
mexR
may be a part of the
mexAB-oprM
promoter.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
125 articles.
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