Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance-Reference-Cited by-同舟云学术

Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Diorio-Toth Luke¹^ORCID,Irum Sidra²,Potter Robert F.¹³,Wallace Meghan A.³,Arslan Muhammad⁴,Munir Tehmina⁵,Andleeb Saadia²,Burnham Carey-Ann D.³⁶⁷⁸^ORCID,Dantas Gautam¹³⁷⁹^ORCID

Affiliation:

1. The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan

3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

4. Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan

5. Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan

6. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

7. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

8. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

9. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA

Abstract

Pseudomonas aeruginosa is associated with serious infections, and treatment can be challenging. Because of this, carbapenems and β-lactam/β-lactamase inhibitor combinations have become critical tools in treating multidrug-resistant (MDR) P. aeruginosa infections, but increasing resistance threatens their efficacy.

Funder

United States Agency for International Development

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00766-22

Reference86 articles.

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